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MECONIUM ILEUS
Mohd Fazrul. 122854
• Neonatal intestinal obstruction secondary to
• Meconium within the lumen of the bowel
that has become thickened
INCIDENCE
can occur in approximately 20% of patients with
cystic fibrosis
RISK FACTORS
1. Family history of
• cystic fibrosis
• meconium ileus
2. low birth weight
PATHOGENESIS
1. Accumulated thickened meconium leads to
obstruction in the bowel lumen resulting in
• dilation of the proximal ileum wall and
• narrowing of the distal intestine
PRESENTATION
• Symptoms
• failure to rectally pass meconium
• Physical exam
• abdominal distension
• palpable bowel loops
• may have visible peristaltic waves
DIFFERENTIAL DIAGNOSIS
1. Intestinal atresia
2. Hirschsprung disease
3. Volvulu
TREATMENT
1. Non-operative
Hyperosmolar enema (e.g., Gastrografin)
 indication
• this is a non-operative approach to treat meconium ileus as this leads to
 breakdown of the thickened meconium which clears the obstruction
• this is typically performed in simple meconium ileus but
 can be used in complicated meconium ileus
2. Operative
Resection with enterostomy or primary anastomosis
 indication
• can be used in cases of simple meconium ileus that does not clear with
hyperosmolar enema
• this is typically performed in complicated meconium ileus
REFERENCE

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Meconium ileus Simple

  • 2. • Neonatal intestinal obstruction secondary to • Meconium within the lumen of the bowel that has become thickened INCIDENCE can occur in approximately 20% of patients with cystic fibrosis RISK FACTORS 1. Family history of • cystic fibrosis • meconium ileus 2. low birth weight PATHOGENESIS 1. Accumulated thickened meconium leads to obstruction in the bowel lumen resulting in • dilation of the proximal ileum wall and • narrowing of the distal intestine
  • 3. PRESENTATION • Symptoms • failure to rectally pass meconium • Physical exam • abdominal distension • palpable bowel loops • may have visible peristaltic waves DIFFERENTIAL DIAGNOSIS 1. Intestinal atresia 2. Hirschsprung disease 3. Volvulu
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  • 5. TREATMENT 1. Non-operative Hyperosmolar enema (e.g., Gastrografin)  indication • this is a non-operative approach to treat meconium ileus as this leads to  breakdown of the thickened meconium which clears the obstruction • this is typically performed in simple meconium ileus but  can be used in complicated meconium ileus 2. Operative Resection with enterostomy or primary anastomosis  indication • can be used in cases of simple meconium ileus that does not clear with hyperosmolar enema • this is typically performed in complicated meconium ileus