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Primary hyperaldosteronism
- 2. DEFINITION Clinical condition where there is hypersecretion of aldosterone leading to sodium retension, pottasium loss and hypertension
- 3. ETIOLOGY Adenoma of zona glomerulosa Bilateral hyperplasia of zona glomerulosa
- 4. PATHOPHYSIOLOGY ALDOSTERONISM Water and soidum retention, and volume expansion Hypertension edema hypokalemia and loss of H+ ION Parasthesias, muscle wekness,depression of tendon reflex, renal dysfunction hypernatremia, polyuria polydipsia, nocturia
- 5. CLINICAL FEATURES Hypertension Edema Hypokalemia Alkalosis Muscle weakness Abdominal distension Periodic muscle weakness Polyuria Tetany ECG changes and arrythmia
- 6. DIAGNOSIS Serum electrolyte Plasma/urinary aldosterone Pasma renin activity CT/MRI abdomen for adrenals
- 7. MANAGEMENT DRUG THERAPY – SPIRONOLACTONE( anti aldosterone) 200-400mg/day+ ACE INHIBITOR for hypertension SURGERY - UNILATERAL ADRENALECTOMY
- 8. Thank you