Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News and Commentary
  • Published:

Metastatic medulloblastoma—therapeutic success through molecular target identification?

The Pharmacogenomics Journal volume 2, pages 7–10 (2002)Cite this article

Metastatic medulloblastoma is a malignant tumor of the developing CNS with little hope for a permanent cure. A report by McDonald et al offers alternatives by identifying potential therapeutic targets using expression array analysis.1,2

The treatment of patients with standard risk tumors, ie those without metastases has been rather successful with survival rates of up to 78%.4,6 In contrast, the cure of metastatic disease has until recently been limited to single cases.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. MacDonald TJ et al . Nat Genet 2001 29: 143–152

    Article  CAS  Google Scholar 

  2. Frühwald MC . In: Schwab M (ed) Encyclopedic Reference of Cancer Springer: Berlin 2001

    Google Scholar 

  3. Packer RJ et al . Neuro-Oncol 1999 1: 232–250

  4. Zeltzer PM et al . J Clin Oncol 1999 17: 832–845

  5. Campbell AN et al . Cancer 1984 53: 974–981

    Article  CAS  Google Scholar 

  6. Kortmann RD et al . Int J Radiat Oncol Biol Phys 2000 46: 269–279

  7. Strother D et al . J Clin Oncol 2001 19: 2696–2704

  8. Palmer SL et al . J Clin Oncol 2001 19: 2302–2308

  9. Biegel JA . Neurooncology 1999 1: 139–151

  10. FruÐhwald MC et al . Oncogene 2001 20: 5033–5042

    Article  Google Scholar 

  11. Kilic T et al . Cancer Res 2000 60: 5143–5150

  12. Adjei AA . J Natl Cancer Inst 2001 93: 1062–1074

  13. Black P et al . Pediatr Neurosurg 1996 24: 74–78

    Article  CAS  Google Scholar 

  14. Schlessinger J . Cell 2000 103: 211–225

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Universitätsklinikum Münster, Klinik und Poliklinik für Kinderheilkunde, Pädiatrische Hämatologie/Onkologie, Münster, Germany

    M C Frühwald

  2. Division of Human Cancer Genetics, The Ohio State University, Columbus, Ohio, USA

    C Plass

Authors
  1. M C Frühwald
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C Plass
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M C Frühwald.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Frühwald, M., Plass, C. Metastatic medulloblastoma—therapeutic success through molecular target identification?. Pharmacogenomics J 2, 7–10 (2002). https://doi.org/10.1038/sj.tpj.6500077

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.tpj.6500077

This article is cited by

Search

Advanced search

Quick links