Extraventricular central neurocytoma can mimic the appearance of other low-grade tumors such as ganglioglioma and DNET. What protein marker on electron microscopy can be used to confirm the diagnosis?
Dr. ERNESTO P.
4mo
“Immunophenotype Immunohistochemistry confirms the purely neuronal origin by positivity to neuronal markers such as: synaptophysin: positive NeuN: positive neurone-specific enolase: positive MAP2: usually positive class III beta-tubulin: usually positive GFAP and IDH-1 R132H are negative.” https://radiopaedia.org/articles/central-neurocytoma
Dr. ERNESTO P.
4mo
The rare extraventricular among the rare central neurocytomas https://radiopaedia.org/articles/extraventricular-neurocytoma-1
E X C E L E N T !!! S U P E R I O R !!! F A N T A S T I C !!! Andreas Peric, M.D. 00382-69-711-822 quest.med01@gmail.com Fenomenal image...congrats..
Radiologue Interventionnel
4mo“The most consistent finding for histological diagnosis was the presence of typical or abortive synapses with clear and dense-core vesicles. Additionally, synaptophysin may be a specific marker for some central neurocytomas” Kubota, T., Hayashi, M., Kawano, H., Kabuto, M., Sato, K., Ishise, J., Kawamoto, K., Shirataki, K., Iizuka, H., & Tsunoda, S. (1991). Central neurocytoma: immunohistochemical and ultrastructural study. Acta neuropathologica, 81(4), 418–427. https://doi.org/10.1007/BF00293463