Anaplastic oligodendroglioma

Anaplastic oligodendroglioma

  • Grade III tumors (Anaplastic oligodendroglioma)
    • Cellular tumors
    • Nuclear hyperchromasia is present
    • Brisk mitotic activity (>6 mitotic figures/10 HPF)
    • Microvascular proliferation (intraluminal endothelial cell proliferation)
    • Necrosis may be present but perinecrotic pseudopalisading is usually absent
    • Eosinophilic “astrocyte like cytoplasm, either with prominent processes that resemble astrocytoma (Gliofibrillary oligodendrocytes) or spindle cell change is seen in grade III neoplasm
    • Well circumscribed epithelioid like appearance
    • Minigemistocytes are common in grade III

 

Anaplastic Oligodendroglioma: Sheets of pleomorphic oligodendrocytes having hyperchromatic nuclei and clear to eosinophilic cytoplasm (H&E,X100)

 

Anaplastic Oligodendroglioma: Sheets of pleomorphic oligodendrocytes having hyperchromatic nuclei and clear to eosinophilic cytoplasm (H&E,X100)

 

Anaplastic Oligodendroglioma: Sheets of pleomorphic oligodendrocytes having hyperchromatic nuclei and clear to eosinophilic cytoplasm (H&E,X100)

 

Anaplastic Oligodendroglioma: Sheets of pleomorphic oligodendrocytes having hyperchromatic nuclei and clear to eosinophilic cytoplasm. Atypical mitotic figures are seen. (H&E,X400)

 

Anaplastic Oligodendroglioma: Sheets of pleomorphic oligodendrocytes having hyperchromatic nuclei and clear to eosinophilic cytoplasm. Atypical mitotic figures are seen. (H&E,X400)

 

Anaplastic Oligodendroglioma: Sheets of pleomorphic oligodendrocytes having hyperchromatic nuclei and clear to eosinophilic cytoplasm (H&E,X400)

 

Anaplastic oligodendroglioma: Areas of necrosis (right) with adjacent foci showing pleomorphic cells having hyperchromatic nuclei (H&E,X100)

 

Anaplastic oligodendroglioma: Areas of necrosis with pleomorphic tumor cells having hyperchromatic nuclei (H&E,X100)

 

Anaplastic oligodendroglioma: Foci of the tumor showing oligodendrocytes with perinuclear halo (H&E,X400)

 

 

Anaplastic oligodendroglioma: Sheets of minigemistocytes and lymphocytic infiltrate (H&E,X100)

 

Anaplastic oligodendrglioma: Sheets of minigemisticytes (H&E,X400)

 

Anaplastic oligodendrocytes: Eosinophilic “astrocyte like cytoplasm, with prominent processes (Gliofibrillary oligodendrocytes) (H&E,X100)

 

Anaplastic oligodendrocytes: Eosinophilic “astrocyte like cytoplasm, with prominent processes (Gliofibrillary oligodendrocytes) (H&E,X400)

 

Anaplastic oligodendrocytes: Eosinophilic “astrocyte like cytoplasm, with prominent processes (Gliofibrillary oligodendrocytes) (H&E,X400)

 

Anaplastic oligodendroglioma: Tumor showing hypercellularity with delicate vascular channels (H&E,X100)

 

Anaplastic oligodendroglioma: tumor cells showing nuclear pleomorphism and atypical mitotic figures (H&E,X400)

 

Anaplastic oligodendroglioma: tumor cells showing nuclear pleomorphism and atypical mitotic figures. Delicate vascular channels are noted. (H&E,X400)