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Chapter 6 - ♂♀Germ Cell Tumors: The Ovary and the Testis

from Section 2 - Ovary and Testis: Similarities and Differences

Published online by Cambridge University Press:  12 February 2019

Maria Rosaria Raspollini
Affiliation:
University Hospital Careggi, Florence
Antonio Lopez-Beltran
Affiliation:
Cordoba University Medical School
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Gynecologic and Urologic Pathology
Similarities, Differences and Challenges
, pp. 84 - 102
Publisher: Cambridge University Press
Print publication year: 2019

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References

Kurman, R.J., Carcangiu, M.L., Herrington, C.S., Young, R.H.. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Female Reproductive Organs. Lyon, France: IARC Press; 2014.Google Scholar
Moch, H., Humphrey, P.A., Ulbright, T.M., Reuter, V.E.. WHO Classification of Tumours of the Urinary System and Male Genital Organs, 4th edn., Vol. 8. Lyon, France: IARC Press; 2016.Google Scholar
Mostofi, F.K., Sesterhenn, I.A.. Pathology of germ cell tumors of the testes. Prog Clin Biol Res 1985; 203: 134.Google Scholar
Bredael, J.J., Vugrin, D., Whitmore, W.T. Jr. Autopsy findings in 154 patients with germ cell tumors of the testis. Cancer 1982; 50: 548551.3.0.CO;2-2>CrossRefGoogle ScholarPubMed
Czaja, J.T., Ulbright, T.M.. Evidence for the transformation of seminoma to yolk sac tumor, with histogenetic considerations. Am J Clin Pathol 1992; 97: 468477.CrossRefGoogle ScholarPubMed
Monaghan, P., Raghavan, D., Neville, M.. Ultrastructure of xenografted human germ cell tumors. Cancer 1982; 49: 683697.Google Scholar
Geurts van Kessel, A., Suijkerbuijk, R.F., Sinke, R.J., et al. Molecular cytogenetics of human germ cell tumours: i(12p) and related chromosomal anomalities. Eur Urol 1993; 23: 2328.Google Scholar
Norris, H.J., Zirkin, H.J., Benson, W.L.. Immature (malignant) teratoma of the ovary: a clinical and pathologic study of 58 cases. Cancer 1976; 37: 23592372.3.0.CO;2-Q>CrossRefGoogle ScholarPubMed
Yanai-Inbar, I., Scully, R.E.. Relation of ovarian dermoid cysts and immature teratomas: an analysis of 350 cases of immature teratoma and 10 cases of dermoid cyst with microscopic foci of immature tissue. Int J Gynecol Pathol 1987; 6: 203212.Google Scholar
Baker, B.A., Frickey, L., Yu, I.T., et al. DNA content of ovarian immature teratomas and malignant germ cell tumors. Gynecol Oncol 1998; 71: 1418.Google Scholar
Reyes, A., Moran, C.A., Suster, S., et al. Neuroendocrine carcinomas (carcinoid tumor) of the testis: a clinicopathologic and immunohistochemical study of ten cases. Am J Surg Pathol 2003; 120: 182187.Google Scholar
Merino, J., Zuluaga, A., Gutierrez-Tejero, F., et al. Pure testicular carcinoid associated with intratubular germ cell neoplasia. J Clin Pathol 2005; 58: 13311333.CrossRefGoogle ScholarPubMed
Burke, A.P., Mostofi, F.K.. Placental alkaline phosphatase immunohistochemistry of intratubular malignant germ cells and associated testicular germ cell tumors. Hum Pathol 1988; 19: 663670.CrossRefGoogle ScholarPubMed
Hustin, J., Collette, J., Franchimont, P.. Immunohistochemical demonstration of placental alkaline-phosphatase in various states of testicular development and in germ-cell tumors. Int J Androl 1987; 10: 2935.Google Scholar
Jacobsen, G.K., Norgaard-Pedersen, B.. Placental alkaline phosphatase in testicular germ cell tumours and in carcinoma-in-situ of the testis: an immunohistochemical study. Acta Pathol Microbiol Immunol Scand A 1984; 92: 323329.Google ScholarPubMed
Loftus, B.M., Gilmartin, L.G., O’Brien, M.J., et al. Intratubular germ cell neoplasia of the testis: identification by placental alkaline phosphatase immunostaining and argyrophilic nucleolar organizer region quantification. Hum Pathol 1990; 21: 941948.CrossRefGoogle ScholarPubMed
Krabbe, S., Skakkebaek, N.E., Berthelsen, J.G., et al. High incidence of undetected neoplasia in malescended testes. Lancet 1979; 1: 9991000.Google Scholar
Jones, T.D., Ulbright, T.M., Eble, J.N., et al. OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma. Am J Surg Pathol 2004; 28: 935940.Google Scholar
Jones, T.D., Ulbright, T.M., Eble, J.N., et al. OCT4: a sensitive and specific biomarker for intratubular germ cell neoplasia of the testis. Clin Cancer Res 2004; 10(24): 85448547.CrossRefGoogle ScholarPubMed
de Jong, J., Stoop, H., Dohle, G.R., et al. Diagnostic value of OCT3/4 for pre-invasive and invasive testicular germ cell tumours. J Pathol 2005; 206: 242249.Google Scholar
Sung, M.T., Jones, T.D., Beck, S.D., et al. OCT4 is superior to CD30 in the diagnosis of metastatic embryonal carcinomas after chemotherapy. Hum Pathol 2006; 37: 662667.CrossRefGoogle ScholarPubMed
Rajpert-De Meyts, E., Skakkebaek, N.E.. Expression of the c-kit protein product in carcinoma-in-situ and invasive testicular germ cell tumours. Int J Androl 1994; 17: 8592.CrossRefGoogle ScholarPubMed
American Joint Committee on Cancer (AJCC); Amin, M.B, Edge, S, Greene, F, et al., editors, Staging Manual, 8th edn. London, UK: Springer Education; 2017.CrossRefGoogle ScholarPubMed
Leroy, X., Augusto, D., Leteurtre, E., et al. CD30 and CD117 (c-kit) used in combination are useful for distinguishing embryonal carcinoma from seminoma. J Histochem Cytochem 2002; 50: 283285.CrossRefGoogle ScholarPubMed
Lau, S.K., Weiss, L.M., Chu, P.G.. D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30. Mod Pathol 2007; 20: 320325.CrossRefGoogle ScholarPubMed
Bode, P.K., Barghorn, A., Fritzsche, F.R., et al. MAGEC2 is a sensitive and novel marker for seminoma: a tissue microarray analysis of 325 testicular germ cell tumors. Mod Pathol 2011; 24: 829835.Google Scholar
Cheng, L., Sung, M.T., Cossu-Rocca, P., et al. OCT4: biological functions and clinical applications as a marker of germ cell neoplasia. J Pathol 2007; 211: 19.Google Scholar
Looijenga, L.H., Stoop, H., de Leeuw, H.P., et al. POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. Cancer Res 2003; 63: 22442250.Google Scholar
Ulbright, T.M., Tickoo, S.K., Berney, D.M., et al. Best practices recommendations in the application of immunohistochemistry in testicular tumors: report from the International Society of Urologic Pathology Consensus Conference. Am J Surg Pathol 2014; 38: e35e49.Google Scholar
Idrees, M., Saxena, R., Cheng, L., et al. Podoplanin, a novel marker for seminoma: a comparison study evaluating immunohistochemical expression of podoplanin and OCT3/4. Ann Diagn Pathol 2010; 14: 331336.Google Scholar
Yu, H., Pinkus, G.S., Hornick, J.L.. Diffuse membranous immunoreactivity for podoplanin (D2-40) distinguishes primary and metastatic seminomas from other germ cell tumors and metastatic neoplasms. Am J Clin Pathol 2007; 128: 767775.Google Scholar
de Jong, J., Stoop, H., Gillis, A.J., et al. Differential expression of SOX17 and SOX2 in germ cells and stem cells has biological and clinical implications. J Pathol 2008; 215: 2130.Google Scholar
Nonaka, D.. Differential expression of SOX2 and SOX17 in testicular germ cell tumors. Am J Clin Pathol 2009; 131: 731736.CrossRefGoogle ScholarPubMed
Cheville, J.C., Rao, S., Iczkowski, K.A., et al. Cytokeratin expression in seminoma of the human testis. Am J Clin Pathol 2000; 113: 583588.Google Scholar
Niehans, G.A., Manivel, J.C., Copland, G.T., et al. Immunohistochemistry of germ cell and trophoblastic neoplasms. Cancer 1988; 62: 11131123.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
Berney, D.M., Shamash, J., Pieroni, K., et al. Loss of CD30 expression in metastatic embryonal carcinoma: the effects of chemotherapy? Histopathology 2001; 39: 382385.Google Scholar
Pallesen, G., Hamilton-Dutoit, S.J.. Ki-1 (CD30) antigen is regularly expressed in tumor cells of embryonal carcinoma. Am J Pathol 1988; 133: 446450.Google Scholar
Hittmair, A., Rogatsch, H., Hobisch, A., et al. CD30 expression in seminoma. Hum Pathol 1996; 27: 11661171.Google Scholar
Ferreiro, J.A.. Ber-H2 expression in testicular germ cell tumors. Hum Pathol 1994; 25(5): 522524.Google Scholar
Gopalan, A., Dhall, D., Olgac, S., et al. Testicular mixed germ cell tumors: a morphological and immunohistochemical study using stem cell markers, OCT3/4, SOX2 and GDF3, with emphasis on morphologically difficult-to-classify areas. Mod Pathol 2009; 22: 10661074.Google Scholar
McNamee, T., Damato, S., McCluggage, W.G.. Yolk sac tumours of the female genital tract in older adults derive commonly from somatic epithelial neoplasms: somatically derived yolk sac tumours. Histopathology 2016; 69: 739751.Google Scholar
Eglen, D.E., Ulbright, T.M.. The differential diagnosis of yolk sac tumor and seminoma. Usefulness of cytokeratin, alpha-fetoprotein, and alpha-1-antitrypsin immunoperoxidase reactions. Am J Clin Pathol 1987; 88: 328332.CrossRefGoogle ScholarPubMed
Kao, C.S., Idrees, M.T., Young, R.H., et al. Solid pattern yolk sac tumor in testicular germ cell tumors: a morphologic and immunohistochemical study of 52 cases. Am J Surg Pathol 2012; 36: 360367.CrossRefGoogle ScholarPubMed
Ota, S., Hishinuma, M., Yamauchi, N., et al. Oncofetal protein glypican-3 in testicular germ-cell tumor. Virchows Arch 2006; 449: 308314.CrossRefGoogle ScholarPubMed
Zynger, D.L., Dimov, N.D., Luan, C., et al. Glypican 3: a novel marker in testicular germ cell tumors. Am J Surg Pathol 2006; 30: 15701575.Google Scholar
Zynger, D.L., McCallum, J.C., Luan, C., et al. Glypican 3 has a higher sensitivity than alpha-fetoprotein for testicular and ovarian yolk sac tumour: immunohistochemical investigation with analysis of histological growth patterns. Histopathology 2010; 56: 750757.Google Scholar
Cao, D., Li, J., Guo, C.C., et al. SALL4 is a novel diagnostic marker for testicular germ cell tumors. Am J Surg Pathol 2009; 33: 10651077.CrossRefGoogle ScholarPubMed
Alvarado-Cabrero, I., Hernández-Toriz, N., Paner, G.P.. Clinicopathologic analysis of choriocarcinoma as a pure or predominant component of germ cell tumor of the testis. Am J Surg Pathol 2014; 38(1): 111118.Google Scholar
Miettinen, M., Wang, Z., McCue, P.A., et al. SALL4 expression in germ cell and non germ-cell tumors: a systematic immunohistochemical study of 3215 cases. Am J Surg Pathol 2014; 38: 410420.CrossRefGoogle ScholarPubMed
Looijenga, L.H.. Human testicular (non)seminomatous germ cell tumours: the clinical implications of recent pathobiological insights. J Pathol 2009; 218: 146162.CrossRefGoogle ScholarPubMed
Gopalan, A., Dhall, D., Olgac, S., et al. Testicular mixed germ cell tumors: a morphological and immunohistochemical study using stem cell markers OCT3/4, SOX2, and CDF3 with emphasis on morphologically difficult to classify areas. Mod Pathol 2009; 22: 10661074.Google Scholar
Mikuz, G.. Clinical Pathology of Urologic Tumors. London, UK: Informa Health Care; 2006.Google Scholar
Kraggerud, S.M., Berner, A., Bryne, M., et al. Spermatocytic seminoma as compared to classical seminoma: an immunohistochemical and DNA flow cytometric study. APMIS 1999; 107: 297302.Google Scholar
Kato, K., Ijiri, R., Tanaka, Y., et al. Testicular immature teratoma with primitive neuroectodermal tumor in early chilhood. J Urol 2000; 164: 20682069.Google Scholar

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