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Medulloblastoma Model

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Animal Models of Brain Tumors

Part of the book series: Neuromethods ((NM,volume 77))

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Abstract

Medulloblastoma, the largest group of embryonal brain tumors, is highly aggressive, with a dismal prognosis for high-risk patients. This disease has historically been classified into five variants based on histopathology. Recent genetic, epigenetic, and transcriptional analyses have categorized tumors into 4–6 subgroups, which are often inconsistent with histopathology subclasses. Mouse models of medulloblastoma are key to improving our understanding of disease progression and developing targeted therapies for patients. In this chapter, we describe different genetically engineered mouse models, and how they fit in the molecular and histopathological subclasses of human medulloblastoma. We discuss the strengths and weaknesses with which these mouse models mirror human disease, highlighting how insights from these models have informed initiation and progression of disease. Lastly, we review targeted therapeutic agent testing in some of these models and discuss future steps and goals in medulloblastoma modeling and research.

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Author information

Authors and Affiliations

  1. The W.A. Weiss Lab, University of California, San Francisco, San Francisco, CA, USA

    Jasmine Lau

  2. Departments of Neurology, Pediatrics, and Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA

    William A. Weiss

Authors
  1. Jasmine Lau
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  2. William A. Weiss
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Editors and Affiliations

  1. Instituto Cajal, Molecular, Cellular & Developmental Neur, CSIC, Avda. Doctor Arce 37, Madrid, 28002, Spain

    Ricardo Martínez Murillo

  2. de la Rioja (CIBIR), Oncology Area, Centro de Investigación Biomédica, C/ Piqueras 98, Logroño, 26006, Spain

    Alfredo Martínez

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© 2012 Springer Science+Business Media, LLC

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Lau, J., Weiss, W.A. (2012). Medulloblastoma Model. In: Martínez Murillo, R., Martínez, A. (eds) Animal Models of Brain Tumors. Neuromethods, vol 77. Humana Press, Totowa, NJ. https://doi.org/10.1007/7657_2012_37

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  • DOI: https://doi.org/10.1007/7657_2012_37

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-208-7

  • Online ISBN: 978-1-62703-209-4

  • eBook Packages: Springer Protocols

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