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Breast

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Essentials of Anatomic Pathology

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Abstract

This chapter reviews the clinical, macroscopic, microscopic, and molecular features as well as the differential diagnosis of the most common breast lesions seen in a routine surgical pathology practice. We review the reporting requirements, components of histologic grading, axillary lymph node status, testing for predictive markers (estrogen and progesterone receptor and HER2), as well as the molecular genetics of breast cancer, including the “intrinsic” subtypes. We include a quick review of metastases to the breast and the TNM classification of breast cancer. Applicable ancillary testing modalities and tables and photomicrographs are included to facilitate the use of this chapter as a quick reference guide to the surgical pathology of the breast.

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Authors and Affiliations

  1. Department of Pathology, PeaceHealth Laboratories, Vancouver, WA, USA

    Mohiedean Ghofrani MD, MBA

  2. Department of Pathology, Yale New Haven Hospital and Yale University School of Medicine, New Haven, CT, USA

    Fattaneh A. Tavassoli MD

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  1. Mohiedean Ghofrani MD, MBA
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Correspondence to Fattaneh A. Tavassoli MD .

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Editors and Affiliations

  1. Indiana University School of Medicine, Indianapolis, Indiana, USA

    Liang Cheng

  2. Granger Diagnostics, A Division of Granger Genetics, North Chesterfield, Virginia, USA

    David G. Bostwick

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Ghofrani, M., Tavassoli, F.A. (2016). Breast. In: Cheng, L., Bostwick, D. (eds) Essentials of Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-23380-2_29

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  • DOI: https://doi.org/10.1007/978-3-319-23380-2_29

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