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Twin Reversed Arterial Perfusion Sequence

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Twin and Higher-order Pregnancies

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Abstract

Twin reversed arterial perfusion (TRAP) sequence is an unusual anomaly that only occurs in monochorionic multiple pregnancies. If one twin dies in the early embryonic period, its body may continue to grow, thanks to a reversed perfusion through an artery-to-artery anastomosis by its surviving co-twin. This parasitism puts the healthy survivor at risk of high-output cardiac and demise. In this chapter, we provide up-to-date information on the pathophysiology, diagnosis, and management of this rare anomaly.

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Key Reading

  • Chaveeva P, Poon LC, Sotiriadis A, Kosinski P, Nicolaides KH. Optimal method and timing of intrauterine intervention in twin reversed arterial perfusion sequence: case study and meta-analysis. Fetal Diagn Ther. 2014;35:267–79.

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Disclosure Statement

The author reports no conflict of interest.

Financial Support

LL is the recipient of a grant of “Fonds voor Wetenschappelijk Onderzoek” (FWO grant no: 1804718N).

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Authors and Affiliations

  1. Department of Obstetrics & Gynaecology, University Hospitals Leuven, Leuven, Belgium

    Liesbeth Lewi

  2. Department of Development and Regeneration, Biomedical Sciences, KU Leuven, Leuven, Belgium

    Liesbeth Lewi

Authors
  1. Liesbeth Lewi
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Correspondence to Liesbeth Lewi .

Editor information

Editors and Affiliations

  1. Fetal Medicine Unit, St George’s University Hospitals, NHS Foundation Trust, London, UK

    Asma Khalil

  2. Department of Obstetrics & Gynaecology, University Hospitals Leuven, Leuven, Belgium

    Liesbeth Lewi

  3. Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands

    Enrico Lopriore

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Lewi, L. (2021). Twin Reversed Arterial Perfusion Sequence. In: Khalil, A., Lewi, L., Lopriore, E. (eds) Twin and Higher-order Pregnancies. Springer, Cham. https://doi.org/10.1007/978-3-030-47652-6_17

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  • DOI: https://doi.org/10.1007/978-3-030-47652-6_17

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-47651-9

  • Online ISBN: 978-3-030-47652-6

  • eBook Packages: MedicineMedicine (R0)

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