Abstract
Meconium ileus occurs due to neonatal obstruction of the ileum by abnormally viscid meconium. This condition is most commonly associated with cystic fibrosis but is also observed in premature and very low birth weight infants. Meconium ileus can range from being a benign disease to a severe condition with complicated meconium ileus requiring urgent surgical intervention. This chapter provides an overview of the condition, its pathophysiology, diagnosis, and treatment.
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References
Carlyle BE, Borowitz DS, Glick PL. Operative pediatric surgery – chapter 43 meconium ileus 2014.
Allan DL, Robbie M, Phelan PD. Familial occurrence of meconium ileus. Eur J Pediatr. 1981;135:291–2.
Nandi B, Mungongo C, Lakhoo L. A comparison of neonatal surgical admissions between two linked surgical departments in Africa and Europe. Pediatr Surg Int. 2008;24:939–42.
Naguib ML, Schrijver I, Gardner P, et al. Cystic fibrosis detection in high-risk Egyptian children and CFTR mutation analysis. J Cyst Fibros. 2007;6:111–6.
Adeyemi SD. Neonatal intestinal obstruction in a developing tropical country: patterns, problems, and prognosis. J Trop Pediatr. 1989;35:66–70.
Barrack SM, Kyambi JM, Ndungu J, et al. Intestinal atresia and stenosis as seen and treated at Kenyatta National Hospital, Nairobi. East Afr Med J. 1993;70:558–64.
Mutesa L, Azad AK, Verhaeghe C, et al. Genetic analysis of Rwandan patients with cystic fibrosis–like symptoms: identification of novel cystic fibrosis transmembrane conductance regulator and epithelial sodium channel gene variants. Chest. 2009;135(5):1233–42.
Kopp BT, Nicholson L, Paul G, Tobias J, Ramanathan C, Hayes D Jr. Geographic variations in cystic fibrosis: an analysis of the U.S. CF Foundation Registry. Pediatr Pulmonol. 2015;50(08):754–62.
Rescorla FJ, Grosfeld JL. Contemporary management of meconium ileus. World J Surg. 1993;17:318–25.
Rickham PP, Boeckman CR. Neonatal meconium obstruction in the absence of mucoviscidosis. Am J Surg. 1965;109:173–7.
Siddiqui MM, Drewett M, Burge DM. Meconium obstruction of prematurity. Arch Dis Child Fetal Neonatal Ed. 2012;297:F147–50.
Emil S. Meconium obstruction in the very low birth weight premature infant. Pediatrics. 2004;114:1367. Author reply, 1367–1368.
Jhaveri MK, Kumar SP. Passage of the first stool in very low birth weight infants. Pediatrics. 1987;79:1005–7.
McLain CR. Amniography studies of the gastrointestinal motility of the human fetus. Am J Obstet Gynecol. 1963;86:1089–7.
Milla PJ. Development of intestinal structure and function in neonatal gastroenterology. Neonatal gastroenterology: contemporary issues 1984:1–20.
Yoo SY, Jung SH, Eom M, et al. Delayed maturation of interstitial cells of Cajal in meconium obstruction. J Pediatr Surg. 2002;37:1758–61.
Emery JL. Abnormalities in meconium of the foetus and newborn. Arch Dis Child. 1957;32:17–21.
Hutchinson HT, Nichols MM, Kuhn CR, et al. Effects of magnesium sulfate on uterine contractility, intrauterine fetus and infant. Am J Obstet Gynecol. 1964;88:747–58.
O’Sullivan BP, Freedman SD. Cystic fibrosis. Lancet. 2009;373(9678):32–40.
Reid JR. Practical imaging approach to bowel obstruction in neonates: a review and update. Semin Roentgenol. 2011;47(1):21–31.
Sathe M, Houwen R. Meconium ileus in cystic fibrosis. J Cyst Fibros. 2017;16:32–29.
Noblett HR. Treatment of uncomplicated meconium ileus by gastrografin enema: a preliminary report. J Pediatr Surg. 1969;4:190–7.
Karimi A, Gorter RR, Sleeboom C, Kneepkens CM, Heij HA. Issues in the management of simple and complex meconium ileus. Pediatr Surg Int. 2011;27(9):963.
Harberg FJ, Senekjian EK, Pokorny WJ. Treatment of uncomplicated meconium ileus via T-tube ileostomy. J Pediatr Surg. 1981;16:61–3.
Millar AJW, Rode H, Cywes S. Management of uncomplicated meconium ileus with T tube ileostomy. Arch Dis Child. 1988;63(3):309–10.
Mak GZ, Harberg FJ, Hiatt P, Deaton A, Calhoon R, Brandt ML. T-tube ileostomy for meconium ileus: four decades of experience. J Pediatr Surg. 2000;35(2):349–52.
Hasan MS, Mitul AR, Karim S, Noor-ul FKM, Kabirul IM. Comparison of T tube ileostomy and Bishop Koop Ileostomy for the management of uncomplicated meconium ileus. J Neonatal Surg. 2017;6(3):56.
Carlyle BE, Borowitz DS, Glick PL. A review of pathophysiology and management of fetuses and neonates with meconium ileus for the pediatric surgeon. J Pediatr Surg. 2012;47(4):772–81.
Stewart C, Pepper MS. Cystic fibrosis on the African continent. Genet Med. 2016;18:653–62.
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Shah, K., Drews, J., Eckoldt-Wolke, F., Abubakar, A.M., Nwomeh, B.C., Seyi-Olajide, J.O. (2020). Meconium Ileus. In: Ameh, E.A., Bickler, S.W., Lakhoo, K., Nwomeh, B.C., Poenaru, D. (eds) Pediatric Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-41724-6_67
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