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Neoplasms in Struma Ovarii: A Review

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Abstract

Struma ovarii is a well-known ovarian teratoma made up of benign thyroid tissue. These lesions demonstrate variable, normal architecture and normal thyroid immunohistochemical staining with positivity for TTF1, PAX8, and thyroglobulin. Though most are benign, some of these lesions can also present with a malignant component. Within this article, we review the most common diagnostic malignancies including papillary thyroid carcinoma, strumal carcinoid, highly differentiated follicular thyroid carcinoma, and other thyroid carcinomas. We additionally review the use of TTF1 staining to assist in differentiating these lesions from surrounding gynecologic epithelium, which is imperative in making such diagnoses. In highlighting these entities, we hope to provide practicing pathologists with an effective and concise review of these lesions to assist in more challenging cases of struma ovarii.

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Author notes

  1. Isabella Tondi Resta and Christopher M. Sande contributed equally to this work.

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104, USA

    Isabella Tondi Resta & Virginia A. LiVolsi

  2. Department of Laboratories, Seattle Children’s Hospital, Seattle, WA, 98105, USA

    Christopher M. Sande

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  1. Isabella Tondi Resta
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I.T. and C.S. contributed equally to the writing and image submission of this manuscript. All authors reviewed the manuscript.

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Correspondence to Isabella Tondi Resta.

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Tondi Resta, I., Sande, C.M. & LiVolsi, V.A. Neoplasms in Struma Ovarii: A Review. Endocr Pathol 34, 455–460 (2023). https://doi.org/10.1007/s12022-023-09789-7

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