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A case of subependymal giant cell astrocytoma without tuberous sclerosis complex and review of the literature

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Abstract

Subependymal giant cell astrocytoma (SEGA) is a World Health Organization (WHO) grade I tumor most commonly seen in the context of the underlying tuberous sclerosis complex (TSC). SEGA in the absence of TSC is exceedingly rare. We report the youngest known case of SEGA in the absence of genetic or phenotypic evidence of TSC with a 10-year follow-up. We discuss the literature surrounding isolated SEGA including an approach to diagnosis, management, and prognosis.

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Authors and Affiliations

  1. Department of Neurosurgery, Neurosurgical Service of Western Australia, Sir Charles Gairdner Hospital, 1st Floor, G Block, Nedlands, Perth, WA, 6009, Australia

    Michael O’Rawe, Arjun S. Chandran, Alexandre Simonin & Sharon Lee

  2. Department of Neurosurgery, Perth Children’s Hospital, Perth, WA, Australia

    Arjun S. Chandran & Sharon Lee

  3. Department of Neurology, Sir Charles Gairdner Hospital, Perth, WA, Australia

    Stuti Joshi

  4. PathWest Neuropathology, Royal Perth Hospital, Perth, WA, Australia

    Jason M. Dyke

Authors
  1. Michael O’Rawe
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  2. Arjun S. Chandran
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  3. Stuti Joshi
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  4. Alexandre Simonin
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  5. Jason M. Dyke
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  6. Sharon Lee
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Correspondence to Arjun S. Chandran.

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O’Rawe, M., Chandran, A.S., Joshi, S. et al. A case of subependymal giant cell astrocytoma without tuberous sclerosis complex and review of the literature. Childs Nerv Syst 37, 1381–1385 (2021). https://doi.org/10.1007/s00381-020-04823-z

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  • DOI: https://doi.org/10.1007/s00381-020-04823-z

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