Abstract
Objectives
To increase our understanding of the imaging features of central neurocytoma (CN) and improve the preoperative MRI diagnosis accuracy.
Methods
Preoperative MR images of 30 CNs and another 68 intraventricular non-CN tumours were analysed by one experienced neuroradiologist retrospectively to identify previously reported features and new features of CN. Six blinded radiologists independently reviewed all these MRI images, and scored all characteristic features on a five-point scale. Diagnostic value was assessed by the area under the receiver operating characteristic curve (AUC); sensitivity, specificity and accuracy were also calculated.
Results
In addition to the ‘scalloping’ sign, ‘broad-based attachment’ sign and ‘soap-bubble’ sign, three new MRI features of CN were identified, including the ‘peripheral cysts’ sign, ‘fluid-fluid level’ sign and the ‘gemstone’ sign. The scalloping sign showed the highest AUC value (0.82), followed by the peripheral cysts sign (0.75) and broad-based attachment sign (0.75). The scalloping sign exhibited the highest specificity (82%), followed by the fluid-fluid level sign (79%) and gemstone (78%) sign. The broad-based attachment sign (85%) was the most sensitive feature, followed by the soap-bubble sign (84%) and peripheral cysts sign (77%).
Conclusion
There are six characteristic MRI features that help to improve the preoperative diagnostic accuracy of CN.
Key Points
• This study is the largest magnetic resonance imaging (MRI) cohort on central neurocytoma (CN).
• Three new features helpful for the diagnosis of CN were reported.
• Diagnostic value of six MRI features of CN was preliminarily determined.
Similar content being viewed by others
Abbreviations
- AUC:
-
Area under the curve
- CN:
-
Central neurocytoma
- ROC:
-
Receiver operating characteristic
- SE:
-
Standard error
References
Hassoun J, Gambarelli D, Grisoli F et al (1982) Central neurocytoma. An electron-microscopic study of two cases. Acta Neuropathol 2:151–156
Louis DN, Perry A, Reifenberger G et al (2016) The 2016 world health organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 6:803–820
Koeller KK, Sandberg GD (2002) From the archives of the afip. Cerebral intraventricular neoplasms: radiologic-pathologic correlation. Radiographics 6:1473–1505
Donoho D, Zada G (2015) Imaging of central neurocytomas. Neurosurg Clin N Am 1:11–19
Chen CL, Shen CC, Wang J, Lu CH, Lee HT (2008) Central neurocytoma: a clinical, radiological and pathological study of nine cases. Clin Neurol Neurosurg 2:129–136
Kerkovsky M, Zitterbart K, Svoboda K et al (2008) Central neurocytoma: the neuroradiological perspective. Childs Nerv Syst 11:1361–1369
Niiro T, Tokimura H, Hanaya R et al (2012) Mri findings in patients with central neurocytomas with special reference to differential diagnosis from other ventricular tumours near the foramen of monro. J Clin Neurosci 5:681–686
Goergen SK, Gonzales MF, Mclean CA (1992) Interventricular neurocytoma: radiologic features and review of the literature. Radiology 3:787–792
Shin JH, Lee HK, Khang SK et al (2002) Neuronal tumors of the central nervous system: radiologic findings and pathologic correlation. Radiographics 5:1177–1189
Ramsahye H, He H, Feng X, Li S, Xiong J (2013) Central neurocytoma: radiological and clinico-pathological findings in 18 patients and one additional mrs case. J Neuroradiol 2:101–111
Smith AB, Smirniotopoulos JG, Horkanyne-Szakaly I (2013) From the radiologic pathology archives: intraventricular neoplasms: radiologic-pathologic correlation. Radiographics 1:21–43
Freund M, Jansen O, Geletneky K, Hahnel S, Sartor K (1998) Computerized tomography and magnetic resonance imaging findings in central neurocytoma. Rofo 5:502–507
Choudhari KA, Kaliaperumal C, Jain A et al (2009) Central neurocytoma: a multi-disciplinary review. Br J Neurosurg 6:585–595
Zhang D, Wen L, Henning TD et al (2006) Central neurocytoma: clinical, pathological and neuroradiological findings. Clin Radiol 4:348–357
Wang M, Jia D, Shen J, Zhang J, Li G (2013) Clinical and imaging features of central neurocytomas. J Clin Neurosci 5:679–685
Osztie E, Hanzely Z, Afra D (2009) Lateral ventricle gliomas and central neurocytomas in adults diagnosis and perspectives. Eur J Radiol 1:67–73
Jouvet A, Lellouch-Tubiana A, Boddaert N, Zerah M, Champier J, Fevre-Montange M (2005) Fourth ventricle neurocytoma with lipomatous and ependymal differentiation. Acta Neuropathol 3:346–351
Paek SH, Kim JE, Kim DG, Han MH, Jung HW (2003) Angiographic characteristics of central neurocytoma suggest the origin of tumor. J Korean Med Sci 4:573–580
von Deimling A, Kleihues P, Saremaslani P et al (1991) Histogenesis and differentiation potential of central neurocytomas. Lab Invest 4:585–591
Cheung YK (1996) Central neurocytoma occurring in the thalamus: ct and mri findings. Australas Radiol 2:182–184
Nishio S, Tashima T, Takeshita I, Fukui M (1988) Intraventricular neurocytoma: clinicopathological features of six cases. J Neurosurg 5:665–670
Chang KH, Han MH, Kim DG et al (1993) Mr appearance of central neurocytoma. Acta Radiol 5:520–526
Collins VP, Jones DT, Giannini C (2015) Pilocytic astrocytoma: pathology, molecular mechanisms and markers. Acta Neuropathol 6:775–788
Goel A, Shah A, Jhawar SS, Goel NK (2010) Fluid-fluid level in pituitary tumors: analysis of management of 106 cases. J Neurosurg 6:1341–1346
Funding
This study has received funding by the Natural Science Foundation of Guangdong Province, China, the Science and Technology Program of Guangzhou, China, and the Special Foundation of President of Nanfang Hospital, Southern Medical University.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Guarantor
The scientific guarantor of this publication is Prof. Dr. Yuankui Wu, Department of Medical Imaging, Nanfang Hospital, Southern Medical University.
Conflict of interest
The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
Statistics and biometry
No complex statistical methods were necessary for this paper.
Informed consent
Written informed consent was waived by the Institutional Review Board.
Ethical approval
Institutional Review Board approval was obtained.
Study subjects or cohorts overlap
MRI data of 12 patients of CN have been previously reported in Journal of Neuro-Oncology.
Methodology
• retrospective
• diagnostic or prognostic study
• performed at one institution
Rights and permissions
About this article
Cite this article
Li, X., Guo, L., Sheng, S. et al. Diagnostic value of six MRI features for central neurocytoma. Eur Radiol 28, 4306–4313 (2018). https://doi.org/10.1007/s00330-018-5442-y
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00330-018-5442-y