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MRI findings in children with congenital cytomegalovirus infection retrospectively diagnosed with dried umbilical cord

  • Paediatric Neuroradiology
  • Published:
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Abstract

Purpose

Brain MRI provides important information about suspected congenital CMV infection in neonatally underdiagnosed children. This study aimed to describe MRI findings in children in whom congenital CMV infection was not suspected during the neonatal period and was proven retrospectively.

Methods

We enrolled 31 children referred to the pediatric neurology clinic with neurological symptoms who were proven to have congenital CMV infection based on dried umbilical cord samples. Upon diagnosis, MR and CT images were assessed using the van der Knaap scoring system integrated with additional variables. Two investigators independently assessed all images.

Results

The age at diagnosis was < 12 months in 14, 12–24 months in 11, and > 24 months in 6 patients. The initial symptom triggering clinic referral was delayed development in 22, seizure in 5, deafness in 3, and hemiplegia in 1 patient. Of the 31 children, 30 had a white matter (WM) abnormality predominant in the deep WM of the parietal lobe (n = 25). Anterior temporal lesions were observed in 21 children. Cortical lesions were observed in 7 children, suggestive of polymicrogyria. No child had cerebellar or brainstem abnormalities. Brain CT was performed in 22 of 31 children, and 11 showed punctate cerebral calcification in the periventricular and/or deep WM.

Conclusion

Patients with congenital CMV infection with delayed neurological symptoms show a relatively uniform pattern of parietal-dominant multifocal WM lesions and anterior temporal lesions, with or without polymicrogyria.

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Abbreviations

CMV:

Cytomegalovirus

SGA:

Small for gestational age

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Funding

No funding was received for this study.

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Authors and Affiliations

  1. Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan

    Hiroyuki Kidokoro, Anna Shiraki, Yuka Torii, Masaharu Tanaka, Hiroyuki Yamamoto, Jun Natsume & Yoshinori Ito

  2. Department of Pediatrics, Aichi Medical University, Nagakute, Japan

    Hirokazu Kurahashi & Akihisa Okumura

  3. Division of Pediatric Neurology, Aichi Developmental Disability Center, Kasugai, Japan

    Koichi Maruyama

Authors
  1. Hiroyuki Kidokoro
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  2. Anna Shiraki
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  3. Yuka Torii
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  4. Masaharu Tanaka
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  5. Hiroyuki Yamamoto
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  6. Hirokazu Kurahashi
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  8. Akihisa Okumura
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  9. Jun Natsume
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  10. Yoshinori Ito
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Corresponding author

Correspondence to Hiroyuki Kidokoro.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Contributions

H.K. wrote the first draft and all authors reviewed the final version of the manuscript. H.K. and Y.I. have been principal investigators, and all authors collected the data presented in this paper.

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Kidokoro, H., Shiraki, A., Torii, Y. et al. MRI findings in children with congenital cytomegalovirus infection retrospectively diagnosed with dried umbilical cord. Neuroradiology 63, 761–768 (2021). https://doi.org/10.1007/s00234-020-02603-9

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  • DOI: https://doi.org/10.1007/s00234-020-02603-9

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