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Cri-Du-Chat Syndrome

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Atlas of Genetic Diagnosis and Counseling

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Abstract

Cri du chat syndrome is a chromosome 5p deletion syndrome first described by Lejeune et al. in 1963. The name of the syndrome refers to the most characteristic clinical feature, a high-pitched crying similar to the mewing of a cat, which usually disappears in the first years of life. The incidence is estimated to be approximately 1 in 15,000 (Higurashi et al. 1990) to 1 in 50,000 births (Niebuhr 1978). The prevalence among mentally retarded individuals is approximately 1.5 in 1,000.

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Authors and Affiliations

  1. Medical Genetics, Shriners Hospitals for Children, Perinatal and Clinical Genetics, Department of Pediatrics, LSU Health Sciences Center, Shreveport, LA, USA

    Harold Chen

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  1. Harold Chen
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Chen, H. (2017). Cri-Du-Chat Syndrome. In: Atlas of Genetic Diagnosis and Counseling. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2401-1_60

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  • DOI: https://doi.org/10.1007/978-1-4939-2401-1_60

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-2400-4

  • Online ISBN: 978-1-4939-2401-1

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