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Fight to the death.
These mouse cells in culture, with blue-stained nuclei, are infected by two strains of the banana-shaped parasitic protozoon, Toxoplasma gondii. The parasites of the black strain are coated with the mouse resistance protein, Irgb6, stained red, and will soon die. The green-stained parasites can enzymatically inactivate the resistance proteins. These parasites are therefore virulent and will soon start replicating and spreading from cell to cell. This picture illustrates one component of a complicated contest between polymorphic pathogens and polymorphic hosts. See Fleckenstein et al. (e1001358) in this issue.
Image Credit: Aliaksandr Khaminets and Jonathan Howard
Synopses
When Malaria Slips a Vaccine's Net
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